Alterations of Granulopoiesis Following Chemotherapy
نویسندگان
چکیده
منابع مشابه
Alterations of granulopoiesis following chemotherapy.
Clonal proliferation of marrow granulocytic progenitor cells (GPC) in vitro and the daily urinary output of granulocytic colony-stimulating factor (CSF) were determined in two patients with acute myeloid leukemia (AML) in remission and one patient with malignant lymphoma receiving monthly pulses of chemotherapy with cytosine arabinoside and 6-thioguanine. During and immediately following therap...
متن کاملSplenic Granulopoiesis in Mice following Administrationof Cyclophosphamide1
C57BL x DBA/2 F5mice bred in our laboratory from stock purchased from The Jackson Laboratory, Ban Harbor, Maine, were used in all experiments. Animals were between 8 and 15 weeks of age. Cyclophosphamide (100 mg) with sodium chloride (45 mg) (Mead Johnson Laboratories, Evansville, Ind.) was dissolved in 5 ml preservative-free sterile water and admin istered (200 mg/kg) i.p. Control mice were gi...
متن کاملNormal Granulopoiesis and Its Alterations in Murine Myelogenous Leukemia
This paper presents a review of the current knowledge of the process of granulopoiesis, and the kinetics and control of the process. The author makes a case for the understanding of normal developmental mechanisms and their control as a basis to the study of malignancy. Stimulatory factors regulating the processes of proliferation, maturation, and release of mature granulocytes from the marrow ...
متن کاملModelling human granulopoiesis under poly-chemotherapy with G-CSF support.
Cytotoxic drugs administered in polychemotherapy cause a characteristic neutropenic period depending on the schedule of the drugs, which can partly be prevented by G-CSF growth factor support. To quantify these effects and to gain a deeper insight into the dynamics of bone marrow recovery after such suppressing and stimulating disturbances, we construct a biomathematical compartment model of hu...
متن کاملSplenic granulopoiesis in mice following administration of cyclophosphamide.
The adult mouse spleen retains granulocytic progenitor cells that are capable of proliferation and maturation. In mice given cyclophosphamide, spleen weight and cell content increased. In vitro granulocyte progenitor cells increased more than 300-fold in the spleen and remained elevated 14 days following cyclophosphamide. Proliferative and nonproliferative granulocytes were increased above cont...
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ژورنال
عنوان ژورنال: Blood
سال: 1974
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v44.3.375.375